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In this article we discuss relevant data on aging, longevity, and gender with particular focus on inflammation gene polymorphisms which could affect an individual's chance to reach the extreme limit of human life. The present review is not an extensive revision of the literature, but rather an expert opinion based on selected data from the authors' laboratories.

In in the more women vasto looking for sex regions, the life expectancy at birth is Indeed, gender s for important differences in the prevalence of a variety of age-related diseases. Considering people of far-advanced age, demographic data document a clear-cut prevalence of females compared to males, suggesting that sex-specific mortality rates follow different trajectories during aging. Thus, a complex interaction of environmental, historical, and genetic factors, differently characterizing the various parts of Italy, likely plays an important role in determining the gender-specific probability of achieving longevity.

This women vasto looking for sex be due to gender-specific cultural and anthropological characteristics of Italian society in the last years. There is some suggestion that people genetically predisposed to weak inflammatory activity may be at reduced chance of developing coronary heart disease CHD and, therefore, may achieve longer lifespan if they avoid serious life-threatening infectious disease thoroughout life.

Thus, the pathogen burden, by interacting with host genotype, could determine the type and intensity of the immune-inflammatory response responsible for both proinflammatory status and CHD. These findings point to a strong relationship between the genetics of inflammation, successful aging, and the control of cardiovascular disease, but seem to suggest that the evidence for men is much stronger.

Understanding the different strategies that men and women seem to follow to achieve longevity may help us to comprehend better the basic phenomenon of aging and allow us to search for safe ways to increase male lifespan. Please enable it to take advantage of the complete set of features!

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Immunogenetics, gender, and longevity

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Similar articles Inflammation, longevity, and cardiovascular diseases: role of polymorphisms of TLR4.


Candore G, et al. Ann N Y Acad Sci. PMID: Gender-specific association between IL promoter polymorphism and longevity.

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Lio D, et al. Genes Immun. Do men and women follow different trajectories to reach extreme longevity? Franceschi C, et al. Aging Milano.


PMID: Review. Carrieri G, et al.


Aging Cell. Inflammatory networks in ageing, age-related diseases and longevity.

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Vasto S, et al. Mech Ageing Dev. Epub Nov See all similar articles. Cited by 31 articles Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15, Chinese individuals. Liu X, et al. Epub Mar 3. Ageing Res Rev. Epub Feb Niculet E, et al.

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Aging Albany NY. Online ahead of print. Effects of air pollution on children from a socioecological perspective. In Kim J, et al. BMC Pediatr. See all "Cited by" articles.


Publication types Research Support, Non-U. Gov't Actions. Review Actions. Female Actions. Humans Actions. Immunogenetics Actions. Male Actions. Related information MedGen.